New data suggest that HP1α upregulation is an early event in the transdifferentiation of castration-resistant prostate cancer (CRPC) into the neuroendocrine prostate cancer (NEPC) subtype. Furthermore ...

Our body is constituted of cells that acquired characteristics during development and that fulfill a precise function in each organ: we call these differentiated cells. Generally cells maintain their ...

At the recent American Society of Hematology annual meeting, researchers presented preclinical data examining how transdifferentiation between hematopoietic lineages -- driven by LMO2 expression and ...

Vascular diseases such as atherosclerosis, pulmonary hypertension, and cardiac fibrosis are associated with a reorganization of the structure of blood vessels. Researchers led by the University of ...

Researchers at Baylor College of Medicine have tested the feasibility of using human cell transdifferentiation with RNA sequencing to facilitate diagnoses of Mendelian disorders. The approach ...

The alternative text for this image may have been generated using AI. To their surprise, both groups found that the 'transdifferentiated' cells carried markers for both the ES cells and the adult ...

We report on the case of a 41-year-old man with a 2.1-cm primary malignant melanoma of the skin, located on the crown of the head. The tumor was stage pT4 (with invasion of contiguous structures), ...

Cellular reprogramming is like the fairytale of spinning straw into gold: you take an abundant, mundane cell type, dose it with a cocktail of chemicals, and voilà—now you have an unlimited supply of ...

Direct reprogramming or Transdifferentiation is a way of inducing changes in the cell type from one lineage into another lineage, bypassing pluripotency. This approach is an innovative choice to ...

July 10, 2025 - A research team led by Professor Yiwei Li and Professor Bi-Feng Liu from the College of Life Science and Technology at Huazhong University of Science and Technology (HUST) published an ...

How can a specialized cell change its identity? A research team investigated a 100% effective natural example of this phenomenon, which is called transdifferentiation. This process, by which some ...