Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Correlative cryo-light microscopy and cryo-FIB workflows improve the localization and preparation of intracellular crystals ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

Protein crystallization inside living cells occurs naturally and serves roles such as storage, protection, solid-state catalysis, and, in some cases, arises from progression of disease or infection 1.

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

The ability of single particle cryo-electron microscopy to capture structural information on samples that could not be crystallized for use with crystallographic methods or were too delicate for ...

What is Cryo-Electron Microscopy? Cryo-electron microscopy (cryo-EM) is a powerful technique used to determine the three-dimensional structure of biological macromolecules, such as proteins and ...

Achieving sub-ångström (<1 Å) resolution in electron microscopy typically requires a high-energy (>30 keV) beam and a transmission electron microscope (TEM) fitted with an aberration corrector and a ...

From paints and inks to catalysts and drug-delivery materials, many advanced technologies rely on substances dispersed in organic solvents. Yet directly observing these materials in their native ...

Explore how the National Lab of the Rockies uses advanced microscopy, cryogenic workflows, and automation to connect ...

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